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Notify patients that: Tramadol Hydrochloride Extended-Release is for oral use only and should be swallowed complete. The capsule really should not be chewed, dissolved, crushed or break up. Tramadol Hydrochloride Prolonged-Release may bring about seizures and/or serotonin syndrome with concomitant usage of serotonergic brokers (including SRIs, NRIs